There are increased amount of Ca2+ in homogenate of myocardial tissues,to which may be contributed by the impared activity of Ca2+--pump in sarcoplasmic reticulum.

心衰时心肌组织匀浆中Ca2+增加,可能是肌浆网钙泵活性受损。

Objective: To observe the effect of plasmid DNA on Ca 2+ ATPase activity and ryanodine receptors bound activity in rat skeletal muscle sarcoplasmic reticulum(SR).

目的：观察质粒DNA 对离体大鼠骨骼肌肌质网Ca2+ATPase 活性及ryanodine 受体结合反应的影响。

These observations demonstrate that the spontaneous secretion from isolated myocytes and the effect of ryanodine on ACh-loaded cells are both independent of extracellular Ca~(2+) while Ca~(2+) in the sarcoplasmic reticulum plays a crucial role in the secretions.

这些结果说明加载ACh的肌细胞的自发分泌以及ryanodine对这些细胞的影响都不依赖于细胞外的Ca~(2+)。 由于ryanodine受体位于肌浆网膜上,因而在这种分泌过程中,肌浆网的钙库起着重要的作用。